3-Phenyltoxoflavin |
| رقم الكتالوجGC61582 |
3-فينيل توكسوفلافين ، مشتق من التوكسوفلافين ، هو مثبط Hsp90 ، مع Kd 585 نانومتر لتفاعل Hsp90-TPR2A3-فينيل توكسوفلافين له نشاط مضاد للسرطان
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 32502-63-9
Sample solution is provided at 25 µL, 10mM.
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3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity[1][2].
3-Phenyltoxoflavin (1 nM-100 μM; 4 d) inhibits BT474 cells proliferation in a concentration-dependent manner, with an IC50 of 690 nM[1].3-Phenyltoxoflavin (0.56 nM-100 μM; 2 h) competes with biotinylated Hsp90 peptide for its binding to TPR2A in a dose-dependent manner[1].
[1]. Yi F, et, al. A novel class of small molecule inhibitors of Hsp90. ACS Chem Biol. 2008 Oct 17;3(10):645-54. [2]. Koh S, et, al. A novel light-dependent selection marker system in plants. Plant Biotechnol J. 2011 Apr;9(3):348-58.
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