6-Chloropurine (6-Chloro-9H-purine) |
| رقم الكتالوجGC33332 |
6-كلوروبورين (6-كلورو-9 H-بورين) هو لبنة بناء في التخليق الكيميائي. وسيط في تحضير 9-ألكيل بورين و 6-رنركابتوبورين. أنشطة مكافحة الأورام.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 87-42-3
Sample solution is provided at 25 µL, 10mM.
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6-Chloropurine is a building block in chemical synthesis. Intermediate in the preparation of 9-alkylpurines and 6-rnercaptopurine. Antitumor activities[1].
6-Chloropurine to S-(6-punnyl)glutathione and further metabolism of S-(6-punnyl)glutathione to 6-mercaptopunne may be involved in the mechanism of the 6-Chloropurine-induced antitumor activity[1]. 6-chloropurine and azaserine have been shown to have synergic antitumor properties in a variety of mouse neoplasms when administered simultaneously[1].
[1]. Hwang IY, et al. Detection and mechanisms of formation of S-(6-purinyl)glutathione and 6-mercaptopurine in rats given 6-chloropurine. J Pharmacol Exp Ther. 1993 Jan;264(1):41-6. [2]. Sartorelli AC, et al. Comparative studies on the in vivo action of 6-chloropurine, 6-chloropurine ribonucleoside, and 6-chloro-9-ethylpurine on sarcoma 180 ascites cells. J Pharmacol Exp Ther. 1961 Oct;134:123-8.
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