(S)-3'-hydroxy Blebbistatin (Synonyms: (-)-3'-hydroxy Blebbistatin, meta-hydroxy-Blebbistatin, m-hydroxy-Blebbistatin) |
| رقم الكتالوجGC41484 |
(S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.
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Cas No.: 2097136-42-8
Sample solution is provided at 25 µL, 10mM.
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(S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 µM), while poorly inhibiting smooth muscle myosin (IC50 = 80 µM). Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a 3'-hydroxy group decreases the inherent fluorescence while retaining the activity of (-)-blebbistatin. (S)-3'-hydroxy-Blebbistatin has the same stereochemistry as the active (-)-blebbistatin enantiomer.
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