a-MSH, amide (Synonyms: Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-amide ) |
| رقم الكتالوجGP10060 |
تعمل هرمون ألفا-ميلانوسيت المحفز (a-MSH)، الأميد على تنشيط مستقبل الميلانوكورتين 1 وإشارات رابطة AMP الدورية (cAMP) من خلال ناقل بروتين G، وهذا يؤدي إلى تخصيب صباغ الميلانين.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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a-MSH (α-Melanocyte-Stimulating Hormone), amide engages the melanocortin-1 receptor and activates cyclic AMP (cAMP) signaling via a G-protein transporter, can synthesize melanin. It is an endogenous neuropeptide, a post-translational derivative of pro-opiomelanocortin (POMC). It is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities[1-4,10].
α-MSH-treated(1 hour; 300pg/ml) T cells showed higher levels of protein ubiquitination. Resting T cells treated with alpha-MSH also demonstrated enhanced protein ubiquitination[5].In α-MSH-stimulated(1 µM, 72 h) B16F10 cells, autophagosomes engulfing melanosomes following Pt treatment[6]. α-MSH regulates central nervous system inflammation by acting directly on melanocortin receptors in glial cells. α-MSH regulates the activation of NFκB. α-MSH inhibits nuclear transmigration of transcription factor κB[7].
α-MSH(0.5mg/kg;i.p;28days) modulated the excitatory-inhibitory balance in the brain by restoring GABAergic inhibition and improved cognition in TgCRND8 mice[8]. α-MSH(2, 6, 20 or 60 nmol)plays an important regulatory role in the spinal defecation center of rats. Intrathecal administration of α-MSH in mice can enhance the colonic movement of the L6-S1 spinal cord and block the pelvic nerve, but the pro-kinetic effect of α-MSH disappeared[9].
References:
[1]. Kim MS, Rossi M, et,al.Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone. Diabetes. 2000 Feb;49(2):177-82. doi: 10.2337/diabetes.49.2.177. PMID: 10868932.
[2]. Singh M, Mukhopadhyay K. C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus. Antimicrob Agents Chemother. 2011 May;55(5):1920-9. doi: 10.1128/AAC.00957-10. Epub 2011 Jan 31. PMID: 21282427; PMCID: PMC3088230.
[3]. Catania A, Delgado R, et,al.alpha-MSH in systemic inflammation. Central and peripheral actions. Ann N Y Acad Sci. 1999 Oct 20;885:183-7. doi: 10.1111/j.1749-6632.1999.tb08675.x. PMID: 10816651.
[4]. Anderson EJ, Çakir I, et,al.60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH. J Mol Endocrinol. 2016 May;56(4):T157-74. doi: 10.1530/JME-16-0014. Epub 2016 Mar 3. PMID: 26939593; PMCID: PMC5027135.
[5]. Biros DJ, Namba K, et,al.Alpha-MSH regulates protein ubiquitination in T cells. Cell Mol Biol (Noisy-le-grand). 2006 May 30;52(2):33-8. PMID: 16914084; PMCID: PMC4698146.
[6]. Hseu YC, Vudhya Gowrisankar Y, et,al. The in vitro and in vivo depigmenting activity of pterostilbene through induction of autophagy in melanocytes and inhibition of UVA-irradiated α-MSH in keratinocytes via Nrf2-mediated antioxidant pathways. Redox Biol. 2021 Aug;44:102007. doi: 10.1016/j.redox.2021.102007. Epub 2021 May 19. PMID: 34049220; PMCID: PMC8167190.
[7]. Lipton JM, Zhao H, et,al.Mechanisms of antiinflammatory action of alpha-MSH peptides. In vivo and in vitro evidence. Ann N Y Acad Sci. 1999 Oct 20;885:173-82. doi: 10.1111/j.1749-6632.1999.tb08674.x. PMID: 10816650.
[8]. Biros DJ, Namba K, et,al.Alpha-MSH regulates protein ubiquitination in T cells. Cell Mol Biol (Noisy-le-grand). 2006 May 30;52(2):33-8. PMID: 16914084; PMCID: PMC4698146.
[9].Ueda HH, Naitou K, et,al. α-MSH-induced activation of spinal MC1R but not MC4R enhances colorectal motility in anaesthetised rats. Sci Rep. 2021 Jan 12;11(1):487. doi: 10.1038/s41598-020-80020-x. PMID: 33436759; PMCID: PMC7803980.
[10].Song, X.; Mosby, N.; Yang, J.; Xu, A.; Abdel-Malek, Z.; Kadekaro, A.L. alpha-MSH activates immediate defense responses to UV-induced oxidative stress in human melanocytes. Pigment Cell Melanoma Res. 2009, 22, 809-818.
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