Aminohexylgeldanamycin (Synonyms: AHGDM) |
| رقم الكتالوجGC61563 |
Aminohexylgeldanamycin (AHGDM) ، مشتق Geldanamycin ، هو مثبط قوي HSP90يُظهر Aminohexylgeldanamycin أنشطة مضادة لتولد الأوعية ومضادة للأورام
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Cas No.: 485395-71-9
Sample solution is provided at 25 µL, 10mM.
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Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities[1].
HPMA copolymer-aminohexylgeldanamycin conjugates target cell surface expressed GRP78 in prostate cancer[2].
[1]. Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270. [2]. Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693.
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