BSJ-03-123 |
| رقم الكتالوجGC65128 |
BSJ-03-123 عبارة عن PROTAC متصل بواسطة روابط لـ Cereblon و CDK كمزيل جزيء صغير انتقائي قوي وجديد CDK6
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Cas No.: 2361493-16-3
Sample solution is provided at 25 µL, 10mM.
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BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader.
BSJ-03-123 (BSJ) causes a pronounced anti-proliferative effect in CDK6-dependent AML cell lines by inducing a G1 cell-cycle arrest without a measurable increase in apoptosis[1].
[1]. Brand M, et al. Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9.
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