Cortagine |
| رقم الكتالوجGC50455 |
Cortagine هو ناهض محدد لمستقبلات عامل إفراز الكورتيكوتروبين 1 (CRF1) مع IC50 من 2.6 نانومتر لـ rCRF1
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Potent and selective corticotrophin releasing factor receptor 1 (CRF1) agonist (EC50 = 0.18 nM for rat CRF1). Displays anxiolytic and antidepressant activity in vivo. Microinfusion into mouse prefrontal cortex reduces defensive behavior in vivo.
Tezval et al (2004) Cortagine, a specific agonist of corticotropin-releasing factor receptor subtype 1, is anxiogenic and antidepressive in the mouse model. Proc.Natl.Acad.Sci.U.S.A. 101 9468 PMID:15192151 |Farrokhi et al (2007) Cortagine: behavioral and autonomic function of the selective CRF receptor subtype 1 agonist. CNS Drug Rev. 13 423 PMID:18078427 |Pentkowski et al (2013) Cortagine infused into the medial prefrontal cortex attenuates predator-induced defensive behaviors and Fos protein production in selective nuclei of the amygdala in male CD1 mice. Horm.Behav. 64 519 PMID:23845323
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