Cortagine |
| Catalog No.GC50455 |
Cortagine es un agonista especÍfico del subtipo 1 del receptor del factor liberador de corticotropina (CRF1) con una IC50 de 2,6 nM para rCRF1.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Potent and selective corticotrophin releasing factor receptor 1 (CRF1) agonist (EC50 = 0.18 nM for rat CRF1). Displays anxiolytic and antidepressant activity in vivo. Microinfusion into mouse prefrontal cortex reduces defensive behavior in vivo.
Tezval et al (2004) Cortagine, a specific agonist of corticotropin-releasing factor receptor subtype 1, is anxiogenic and antidepressive in the mouse model. Proc.Natl.Acad.Sci.U.S.A. 101 9468 PMID:15192151 |Farrokhi et al (2007) Cortagine: behavioral and autonomic function of the selective CRF receptor subtype 1 agonist. CNS Drug Rev. 13 423 PMID:18078427 |Pentkowski et al (2013) Cortagine infused into the medial prefrontal cortex attenuates predator-induced defensive behaviors and Fos protein production in selective nuclei of the amygdala in male CD1 mice. Horm.Behav. 64 519 PMID:23845323
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