BTSA1 |
| رقم الكتالوجGC39355 |
BTSA1 هو منشط BAX قوي وعالي التقارب ونشط عن طريق الفم مع IC50 من 250 نانومتر و EC50 من 144 نانومتريرتبط BTSA1 بتقارب وخصوصية عالية بموقع التنشيط N-terminal ويؤدي إلى تغييرات توافقية لـ BAX مما يؤدي إلى موت الخلايا المبرمج بوساطة BAX
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 314761-14-3
Sample solution is provided at 25 µL, 10mM.
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BTSA1 is a potent, high affinity and orally active BAX activator with an IC50 of 250 nM and an EC50 of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis[1].
[1]. Reyna DE, et al. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 2017 Oct 9;32(4):490-505.e10.
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