CYM50358 |
| رقم الكتالوجGC63345 |
CYM50358 هو مضاد S1PR4 قوي وانتقائي ، مع IC50 من 25 نانومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1314212-39-9
Sample solution is provided at 25 µL, 10mM.
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CYM50358 is a potent and selective S1PR4 antagonist, with an IC50 of 25 nM. CYM50358 can be used for the research of influenza infection[1][2].
CYM50358 shows less potent inhibition of S1PR1 (IC50=6.4 μM)[1].CYM50358 (10 μM) has no effect on the collagen-induced HSP27 phosphorylation, markedly reverses the suppressive effect of S1P on the collagen-induced phosphorylation of HSP27[2].
[1]. Guerrero M, et, al. Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3632-6.
[2]. Onuma T, et, al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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