Fz7-21 TFA (Synonyms: Ac-LPSDDLEFWCHVMY-NH2 TFA) |
| رقم الكتالوجGC39383 |
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA هو مضاد ببتيد قوي لمستقبلات FZD7 ، ويرتبط بشكل انتقائي بالفئة الفرعية FZD7 CRD ويغير شكل CRD وبنية أخدود ربط الدهونقيم EC50 هي 58 و 34 نانومتر للإنسان والماوس FZD7 CRD ، على التوالييضعف Fz7-21 TFA وظيفة FZD7 في إشارات Wnt-β-catenin ووظيفة الخلايا الجذعية في العضيات المعوية
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Sample solution is provided at 25 µL, 10mM.
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Fz7-21 TFA ((Ac)-LPSDDLEFWCHVMY-NH2 TFA), a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM)[1].
[1]. Nile AH, et al. Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018 Sep;14(9):902.
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