Fz7-21 TFA (Synonyms: Ac-LPSDDLEFWCHVMY-NH2 TFA) |
| Catalog No.GC39383 |
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA es un potente péptido antagonista de los receptores FZD7, se une selectivamente a la subclase FZD7 CRD y altera la conformaciÓn del CRD y la arquitectura de su ranura de uniÓn a lÍpidos. Los valores EC50 son 58 y 34 nM para FZD7 CRD humano y de ratÓn, respectivamente. Fz7-21 TFA afecta la funciÓn de FZD7 en la seÑalizaciÓn de Wnt-β-catenina y la funciÓn de células madre en organoides intestinales.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Fz7-21 TFA ((Ac)-LPSDDLEFWCHVMY-NH2 TFA), a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM)[1].
[1]. Nile AH, et al. Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018 Sep;14(9):902.
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