Fz7-21 TFA (Synonyms: Ac-LPSDDLEFWCHVMY-NH2 TFA) |
| Catalog No.GC39383 |
Fz7-21(Ac-LPSDDLEFWCHVMY-NH2) TFA는 FZD7 수용체의 강력한 펩타이드 길항제로, FZD7 CRD 하위 클래스에 선택적으로 결합하고 CRD의 형태와 지질 결합 홈의 구조를 변경합니다. EC50 값은 인간 및 마우스 FZD7 CRD에 대해 각각 58 및 34nM입니다. Fz7-21 TFA는 Wnt-β-catenin 신호 전달에서 FZD7의 기능과 장 오르가노이드에서 줄기 세포 기능을 손상시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Fz7-21 TFA ((Ac)-LPSDDLEFWCHVMY-NH2 TFA), a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM)[1].
[1]. Nile AH, et al. Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018 Sep;14(9):902.
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