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(R)-ADX-47273

رقم الكتالوجGC34985

(R) -ADX-47273 هو مُعدِّل خيفي موجب قوي mGluR5 ، مع EC50 من 168 نانومتر للتقوية

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(R)-ADX-47273 التركيب الكيميائي

Cas No.: 851881-59-9

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
119٫00
متوفر
1mg
43٫00
متوفر
5mg
108٫00
متوفر
10mg
176٫00
متوفر
50mg
495٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of (R)-ADX-47273

(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation . mGluR5|168 nM (EC50)

(R)-ADX-47273 (ADX-47273 (5)) is a potent mGluR5 positive allosteric modulator with an EC50 for potentiation of 168 nM and a 9-fold shift of the glutamate response curve at 1 μM[1].

[1]. Engers DW, et al. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr;4(4):505-11.

Chemical Properties of (R)-ADX-47273

Cas No. 851881-59-9 SDF
Canonical SMILES O=C(N1C[C@H](C2=NC(C3=CC=C(C=C3)F)=NO2)CCC1)C4=CC=C(C=C4)F
Formula C20H17F2N3O2 M.Wt 369.36
الذوبان DMSO : 100 mg/mL (270.74 mM; Need ultrasonic) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (R)-ADX-47273

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.7074 mL 13.5369 mL 27.0739 mL
5 mM 0.5415 mL 2.7074 mL 5.4148 mL
10 mM 0.2707 mL 1.3537 mL 2.7074 mL
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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