EIPA hydrochloride (Synonyms: L593754 hydrochloride; MH 12-43 hydrochloride) |
| رقم الكتالوجGC35970 |
هيدروكلوريد EIPA (L593754) هو مثبط قناة TRPP3 نشط عن طريق الفم مع IC50 من 10.5 ميكرومتر
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Cas No.: 1345839-28-2
Sample solution is provided at 25 µL, 10mM.
EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM[1]. EIPA also inhibits Na+/H+-exchanger (NHE)[2] and macropinocytosis[3]. IC50: 10.5 μM (TRPP3 channel)[1]NHE[2]Macropinocytosis[3]
[1]. Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85. [2]. Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429. [3]. Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis.
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