ML-792 |
| رقم الكتالوجGC36631 |
ML-792 هو مثبط قوي وانتقائي لـ SAE / SUMO1 و SAE / SUMO2 في المقايسات الأنزيمية (قيم IC من 3 و 11 نانومتر ، على التوالي) مقارنة مع NAE / NEDD8 و UAE / ubiquitin (قيم IC من 32 ميكرومتر و> 100 ميكرومتر ، على التوالى).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1644342-14-2
Sample solution is provided at 25 µL, 10mM.
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ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50s of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively)[1].
[1]. He X, et al. Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor. Nat Chem Biol. 2017 Nov;13(11):1164-1171.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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