MR-L2 |
| رقم الكتالوجGC36653 |
MR-L2 هو منشط خيفي قابل للانعكاس وغير تنافسي لفوسفوديستراز -4 طويل الشكل (PDE4) ، ينشط المتغيرات النموذجية طويلة الشكل PDE4 (PDE4A4 ، PDE4B1 ، PDE4C3 ، PDE4D5)
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Cas No.: 2374703-19-0
Sample solution is provided at 25 µL, 10mM.
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MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 µM[1]. PDE4[1]
[1]. Omar F, et al. Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329.
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