MR-L2 |
| Catalog No.GC36653 |
MR-L2는 장동형 포스포디에스테라제-4(PDE4)의 가역적이고 비경쟁적 알로스테릭 활성제로 대표적인 PDE4 장동형 변이체(PDE4A4, PDE4B1, PDE4C3, PDE4D5)를 활성화합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2374703-19-0
Sample solution is provided at 25 µL, 10mM.
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MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 µM[1]. PDE4[1]
[1]. Omar F, et al. Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329.
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