MR-L2 |
| Catalog No.GC36653 |
MR-L2 es un activador alostérico reversible y no competitivo de la fosfodiesterasa-4 de isoforma larga (PDE4), activa variantes representativas de isoforma larga de PDE4 (PDE4A4, PDE4B1, PDE4C3, PDE4D5).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2374703-19-0
Sample solution is provided at 25 µL, 10mM.
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MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 µM[1]. PDE4[1]
[1]. Omar F, et al. Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329.
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