PI3K-IN-6 |
Katalog-Nr.GC36908 |
PI3K-IN-6 (Verbindung 20a) ist ein oral aktiver und hochselektiver Phosphoinositid-3-kinase (PI3K)-β/δ-Inhibitor mit IC50-Werten von 7,8 nM bzw. 5,3 nM fÜr PI3K β/δ. PI3K-IN-6 (Verbindung 20a) hat potenziell Top-Treat-Phosphatase- und Tensin-Homolog (PTEN)-defiziente Tumore.
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Cas No.: 1842380-77-1
Sample solution is provided at 25 µL, 10mM.
PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC50 values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors[1]. PI3Kβ|7.8 nM (IC50)|PI3Kδ|5.3 nM (IC50)|PI3Kα|850 nM (IC50)
[1]. Perreault S, et al. Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856. J Med Chem. 2017 Feb 23;60(4):1555-1567.
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