FAK ligand-Linker Conjugate 1 |
| رقم الكتالوجGC38127 |
يشتمل FAK ligand-Linker Conjugate 1 على رابط لـ FAK ، ورابط PROTAC ، والذي يقوم بتجنيد ligases E3 (مثل VHL و CRBN و MDM2 و IAP)يمكن استخدام FAK ligand-Linker Conjugate 1 على نطاق واسع في تحلل البروتين بوساطة PROTAC
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Cas No.: 2307461-45-4
Sample solution is provided at 25 µL, 10mM.
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FAK ligand-Linker Conjugate 1 incorporates a ligand for FAK, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). FAK ligand-Linker Conjugate 1 can be extensively used for PROTAC-mediated protein degradation[1].
[1]. Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026.
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