FAK ligand-Linker Conjugate 1 |
| Catalog No.GC38127 |
El conjugado ligando-enlazador 1 de FAK incorpora un ligando para FAK y un enlazador PROTAC, que recluta ligasas E3 (como VHL, CRBN, MDM2 e IAP). El conjugado 1 de ligando-enlazador FAK se puede utilizar ampliamente para la degradaciÓn de proteÍnas mediada por PROTAC.
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Cas No.: 2307461-45-4
Sample solution is provided at 25 µL, 10mM.
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FAK ligand-Linker Conjugate 1 incorporates a ligand for FAK, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). FAK ligand-Linker Conjugate 1 can be extensively used for PROTAC-mediated protein degradation[1].
[1]. Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026.
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