Polygalacin D |
| رقم الكتالوجGC38545 |
Polygalacin D (PGD) هو مركب نشط بيولوجيًا معزولًا عن Platycodon grandiflorum (Jacq.) مع خصائص مضادة للسرطان ومضادة للتكاثر. يمنع PGD التعبير عن عائلة IAP من البروتينات بما في ذلك survivin و cIAP-1 و cIAP-2 ويمنع PI3K / مسار Akt عن طريق تثبيط فسفرة GSK3β و Akt والتعبير عن PI3KPolygalacin D يستحث موت الخلايا المبرمج
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Cas No.: 66663-91-0
Sample solution is provided at 25 µL, 10mM.
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Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties.PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis[1]
Polygalacin D (0-40 µM; 48 hours) inhibits cell proliferation with IC50s of 26.49 µM in the A549 cells and 20.52 µM in the H460 cells[1].Polygalacin D (0-20 µM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells[1].Polygalacin D (0-20 µM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells[1]. Cell Proliferation Assay[1] Cell Line: A549 and H460 cancer cell lines
[1]. Seo YS, et al. Polygalacin D induces apoptosis and cell cycle arrest via the PI3K/Akt pathway in non-small cell lung cancer. Oncol Rep. 2018 Apr;39(4):1702-1710.
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