Polygalacin D |
| Catalog No.GC38545 |
PGD(Polygalacin D)는 항암 및 항증식 특성을 지닌 Platycodon grandiflorum(Jacq.)에서 분리된 생리활성 화합물입니다. PGD는 survivin, cIAP-1 및 cIAP-2를 포함한 IAP 계열 단백질의 발현을 억제하고 PI3K/ GSK3β, Akt의 인산화 및 PI3K의 발현을 억제함으로써 Akt 경로. 폴리갈라신 D는 세포 사멸을 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 66663-91-0
Sample solution is provided at 25 µL, 10mM.
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Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties.PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis[1]
Polygalacin D (0-40 µM; 48 hours) inhibits cell proliferation with IC50s of 26.49 µM in the A549 cells and 20.52 µM in the H460 cells[1].Polygalacin D (0-20 µM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells[1].Polygalacin D (0-20 µM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells[1]. Cell Proliferation Assay[1] Cell Line: A549 and H460 cancer cell lines
[1]. Seo YS, et al. Polygalacin D induces apoptosis and cell cycle arrest via the PI3K/Akt pathway in non-small cell lung cancer. Oncol Rep. 2018 Apr;39(4):1702-1710.
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