Dihydrokaempferol (Synonyms: (+)-Aromadendrin, (+)-Dihydrokaempferol, Dihydrokaempferol, trans-Dihydrokaempferol) |
| رقم الكتالوجGC38617 |
يتم عزل Dihydrokaempferol من Bauhinia championii (Benth)
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Cas No.: 480-20-6
Sample solution is provided at 25 µL, 10mM.
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Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs[1].
Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs[1].Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively)[1].Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP[1]. Cell Proliferation Assay[1] Cell Line: Normal synoviocyte cells; RA-FLS cells
[1]. Zhang Y, et al. Apoptosis Effects of Dihydrokaempferol Isolated from Bauhinia championii on Synoviocytes. Evid Based Complement Alternat Med. 2018 Dec 2;2018:9806160.
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