GCN2-IN-6 |
| رقم الكتالوجGC39384 |
GCN2-IN-6 (المركب 6d) هو مثبط GCN2 قوي ومتوفر شفهيًا وأكده الإنزيمية الداخلية (IC50 من 1.8 نانومتر) والمقايسات الخلوية (IC50 من 9.3 نانومتر)GCN2-IN-6 هو أيضًا مثبط eIF2α كيناز PERK مع IC 50 من 0.26 نانومتر (في الفحص الأنزيمي) و 230 نانومتر (في الخلايا)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2183470-09-7
Sample solution is provided at 25 µL, 10mM.
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GCN2-IN-6 (Compound 6d) is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8 nM) and cellular assays (IC50 of 9.3 nM). GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells)[1].
[1]. Fujimoto J, et al. Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode. ACS Med Chem Lett. 2019 Sep 19;10(10):1498-1503.
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