GCN2-IN-6 |
| Catalog No.GC39384 |
GCN2-IN-6(화합물 6d)은 사내 효소(IC50 1.8nM) 및 세포 분석(IC50 9.3nM)에 의해 확인된 강력한 경구용 GCN2 억제제입니다. GCN2-IN-6은 또한 IC50이 0.26nM(효소 분석에서) 및 230nM(세포에서)인 eIF2α 키나제 PERK 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2183470-09-7
Sample solution is provided at 25 µL, 10mM.
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GCN2-IN-6 (Compound 6d) is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8 nM) and cellular assays (IC50 of 9.3 nM). GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells)[1].
[1]. Fujimoto J, et al. Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode. ACS Med Chem Lett. 2019 Sep 19;10(10):1498-1503.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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