GCN2-IN-6 |
| Katalog-Nr.GC39384 |
GCN2-IN-6 (Verbindung 6d) ist ein potenter und oral verfÜgbarer GCN2-Inhibitor, der durch interne enzymatische (IC50 von 1,8 nM) und zellulÄre Assays (IC50 von 9,3 nM) bestÄtigt wurde. GCN2-IN-6 ist auch ein eIF2α-Kinase-PERK-Inhibitor mit einem IC50 von 0,26 nM (im enzymatischen Assay) und 230 nM (in Zellen).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2183470-09-7
Sample solution is provided at 25 µL, 10mM.
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GCN2-IN-6 (Compound 6d) is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8 nM) and cellular assays (IC50 of 9.3 nM). GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells)[1].
[1]. Fujimoto J, et al. Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode. ACS Med Chem Lett. 2019 Sep 19;10(10):1498-1503.
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