GCN2-IN-6 |
| Catalog No.GC39384 |
GCN2-IN-6 (composé 6d) est un inhibiteur puissant et disponible par voie orale de GCN2 confirmé par des tests enzymatiques internes (IC50 de 1,8 nM) et cellulaires (IC50 de 9,3 nM). GCN2-IN-6 est également un inhibiteur PERK de la kinase eIF2α avec une IC50 de 0,26 nM (en dosage enzymatique) et de 230 nM (dans les cellules).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2183470-09-7
Sample solution is provided at 25 µL, 10mM.
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GCN2-IN-6 (Compound 6d) is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8 nM) and cellular assays (IC50 of 9.3 nM). GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells)[1].
[1]. Fujimoto J, et al. Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode. ACS Med Chem Lett. 2019 Sep 19;10(10):1498-1503.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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