الصفحة الرئيسية>>Signaling Pathways>> Apoptosis>> RIP kinase>>GSK3145095

GSK3145095

رقم الكتالوجGC15291

GSK3145095 هو مثبط كيناز RIP1 مع IC50 من 6.3 نانومتر.

Products are for research use only. Not for human use. We do not sell to patients.

GSK3145095  التركيب الكيميائي

Cas No.: 1622849-43-7

الحجم السعر المخزون الكميّة
5mg
258٫00
متوفر
25mg
773٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com

مراجعات العميل

بناء على آراء العملاء.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].

IC50: 6.3 nM (RIP1 kinase )[1]

GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC50 = 1.6 nM), cell death as measured by LDH release (IC50 = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1β production, either as absolute levels for protein, or fold changes in mRNA expression (IC50 = 0.4 nM) [1].

Reference:
[1]. Harris PA, ET AL. Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett. 2019 May 9;10(6):857-862.

مراجعات

Review for GSK3145095

Average Rating: 5 ★★★★★ (Based on Reviews and 2 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for GSK3145095

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.