GSK3145095 |
| Catalog No.GC15291 |
GSK3145095 est un inhibiteur de la kinase RIP1 avec une IC50 de 6,3 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1622849-43-7
Sample solution is provided at 25 µL, 10mM.
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GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].
IC50: 6.3 nM (RIP1 kinase )[1]
GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC50 = 1.6 nM), cell death as measured by LDH release (IC50 = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1β production, either as absolute levels for protein, or fold changes in mRNA expression (IC50 = 0.4 nM) [1].
Reference:
[1]. Harris PA, ET AL. Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett. 2019 May 9;10(6):857-862.
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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