IB-MECA (Synonyms: CF-101, IB-MECA) |
رقم الكتالوجGC19197
One-Click Copy Product Info
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IB-MECA (IB-MECA) هو ناهض مستقبلات أدينوزين A3 (A3AR) النشط عن طريق الفم ، وهو الأول من نوعه في فئته.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 152918-18-8
Sample solution is provided at 25 µL, 10mM.
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IB-MECA is an agonist of the adenosine A3 receptor with EC50 values of 0.11 uM. IC50 value: 0.11 uM (EC50) [3]Target: adenosine A3 receptorin vitro: IB-MECA has been shown to play important roles in cell proliferation and apoptosis in a variety of cancer cell lines. TheIB-MECA was capable of decreasing intracellular cyclic adenosine monophosphate (cAMP) that was the reason for the presence of functional A3 adenosine receptor on the cell lines. IB-MECA significantly reduced cell viability in a dose-dependent manner. IB-MECA, an A3AR agonist, inhibits the growth of different cancer cell types like melanoma, colon, breast, leukemia, and prostateIB-MECA was able to inhibit forskolin-stimulated cAMP levels with an EC50 value of 0.82 uM in OVCAR-3 cells. IB-MECA was able to inhibit forskolin-stimulated cAMP levels with an EC50 value of 1.2 uM in Caov-4 cells.in vivo: Administrations of single intraperitoneal doses of either IB-MECA 0.5 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice.[2]
References:
[1]. Hofer M, et al. Agonist of the adenosine A3 receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of γ-irradiated mice. Radiat Environ Biophys. 2014 Mar;53(1):2
[2]. Abedi H, et al. Mitochondrial and caspase pathways are involved in the induction of apoptosis by IB-MECA in ovarian cancer cell lines. Tumour Biol. 2014 Nov;35(11):11027-11039.
[3]. Shin Y, et al. Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-2H3 Mast Cell Line by Adenosine Analogs: Involvement of A(3)-Adenosine Receptors Drug Dev Res. 1996 Sep 1;39(1):36-46.
| Cas No. | 152918-18-8 | SDF | |
| المرادفات | CF-101, IB-MECA | ||
| Canonical SMILES | O[C@H]1[C@H](N2C=NC3=C(NCC4=CC=CC(I)=C4)N=CN=C23)O[C@H](C(NC)=O)[C@H]1O | ||
| Formula | C18H19IN6O4 | M.Wt | 510.29 |
| الذوبان | DMSO : ≥ 45 mg/mL (88.19 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.9597 mL | 9.7983 mL | 19.5967 mL |
| 5 mM | 391.9 μL | 1.9597 mL | 3.9193 mL |
| 10 mM | 196 μL | 979.8 μL | 1.9597 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)