iFSP1 |
| رقم الكتالوجGC45928 |
مثبط لـ AIFM2/FSP1
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 150651-39-1
Sample solution is provided at 25 µL, 10mM.
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iFSP1 is an inhibitor of apoptosis inducing factor mitochondria-associated 2/ferroptosis suppressor protein 1 (AIFM2/FSP1).[1] It decreases cell viability in wild-type, but not glutathione peroxidase 4 (GPX4) knock-out, Pfa1 and HT1080 cells overexpressing AIFM2/FSP1, an effect that can be blocked by the ferroptosis inhibitor liproxstatin-1 . iFSP1 (3 μM) sensitizes a variety of human cancer cell lines to the ferroptosis inducer (1S,3R)-RSL3 .
References:
[1].Doll, S., Freitas, F.P., Shah, R., et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature (2019).
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