KCC 07 |
| رقم الكتالوجGC50520 |
KCC 07 هو مثبط MBD2 قوي وانتقائي ومخترق للدماغ (بروتين مجال ربط الميثيل- CpG 2). يمنع KCC 07 ارتباط MBD2 بالحمض النووي الميثيل وينشط مثبط تكوين الأوعية الدموية 1 (BAI1) الذي يحفز إشارات BAI1 / p53 / p21 المضادة للتكاثر. نشاط مضاد للسرطان.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 315702-75-1
Sample solution is provided at 25 µL, 10mM.
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MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.
Zhu et al (2018) BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 33 1004 PMID:29894688
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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