KCC 07 |
| Katalog-Nr.GC50520 |
KCC 07 ist ein potenter, selektiver und ins Gehirn eindringender MBD2-Inhibitor (Methyl-CpG-binding domain protein 2). KCC 07 verhindert die Bindung von MBD2 an methylierte DNA und aktiviert den gehirnspezifischen Angiogenese-Inhibitor 1 (BAI1), der die antiproliferative BAI1/p53/p21-Signalgebung induziert. Aktivität gegen Krebs.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 315702-75-1
Sample solution is provided at 25 µL, 10mM.
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MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.
Zhu et al (2018) BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 33 1004 PMID:29894688
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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