KCC 07 |
| Catalog No.GC50520 |
KCC 07 es un inhibidor de MBD2 (metil-CpG-binding domain protein 2) potente, selectivo y penetrante en el cerebro. KCC 07 evita la unión de MBD2 al ADN metilado y activa el inhibidor de angiogénesis específico del cerebro 1 (BAI1) que induce la señalización antiproliferativa de BAI1/p53/p21. Actividad anticancerígena.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 315702-75-1
Sample solution is provided at 25 µL, 10mM.
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MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.
Zhu et al (2018) BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 33 1004 PMID:29894688
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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