KDM5A-IN-1 |
| رقم الكتالوجGC32842 |
يعتبر KDM5A-IN-1 مثبطًا قويًا ومتاحًا حيويًا للهيستون ليسين demethylases 5 (KDM5) مع IC50s من 45 نانومتر و 56 نانومتر و 55 نانومتر لـ KDM5A و KDM5B و KDM5C ، على التوالي ، وبقيمة EC50 تبلغ 960 نانومتر لـ PC9 H3K4Me3يعتبر KDM5A-IN-1 أقل فاعلية بشكل ملحوظ مقابل إنزيمات KDM5B الأخرى (1A ، 2B ، 3B ، 4C ، 6A ، 7B)
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Cas No.: 1905481-36-8
Sample solution is provided at 25 µL, 10mM.
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KDM5A-IN-1 is an inhibitor histone demethylases. Target: Histone Demethylase
[1]. Kwong Wah LAI, et al. Pyrrolidine amide compounds as histone demethylase inhibitors. PCT Int. Appl. (2016), WO 2016057924 A1 20160414.
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