الصفحة الرئيسية>>Signaling Pathways>> Chromatin/Epigenetics>> Histone Demethylases>>KDM5A-IN-1

KDM5A-IN-1

رقم الكتالوجGC32842

يعتبر KDM5A-IN-1 مثبطًا قويًا ومتاحًا حيويًا للهيستون ليسين demethylases 5 (KDM5) مع IC50s من 45 نانومتر و 56 نانومتر و 55 نانومتر لـ KDM5A و KDM5B و KDM5C ، على التوالي ، وبقيمة EC50 تبلغ 960 نانومتر لـ PC9 H3K4Me3يعتبر KDM5A-IN-1 أقل فاعلية بشكل ملحوظ مقابل إنزيمات KDM5B الأخرى (1A ، 2B ، 3B ، 4C ، 6A ، 7B)

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KDM5A-IN-1 التركيب الكيميائي

Cas No.: 1905481-36-8

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
441٫00
متوفر
1mg
138٫00
متوفر
5mg
321٫00
متوفر
10mg
459٫00
متوفر
50mg
1379٫00
متوفر
100mg
1930٫00
متوفر

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مراجعات العميل

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Sample solution is provided at 25 µL, 10mM.

Description of KDM5A-IN-1

KDM5A-IN-1 is an inhibitor histone demethylases. Target: Histone Demethylase

[1]. Kwong Wah LAI, et al. Pyrrolidine amide compounds as histone demethylase inhibitors. PCT Int. Appl. (2016), WO 2016057924 A1 20160414.

Chemical Properties of KDM5A-IN-1

Cas No. 1905481-36-8 SDF
Canonical SMILES O=C(C1CC1)N[C@@H]2CCN(C(C3=CC(C(C)C)=NN3)=O)C2
Formula C15H22N4O2 M.Wt 290.36
الذوبان DMSO : ≥ 50 mg/mL (172.20 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of KDM5A-IN-1

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.444 mL 17.22 mL 34.44 mL
5 mM 0.6888 mL 3.444 mL 6.888 mL
10 mM 0.3444 mL 1.722 mL 3.444 mL
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In vivo Formulation Calculator (Clear solution) of KDM5A-IN-1

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Review for KDM5A-IN-1

Average Rating: 5 ★★★★★ (Based on Reviews and 13 reference(s) in Google Scholar.)

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