Lenalidomide-C4-NH2 hydrochloride (Synonyms: Cereblon ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride) |
Katalog-Nr.GC60984 |
Lenalidomid-C4-NH2-Hydrochlorid ist der auf Lenalidomid basierende Cereblon-Ligand, der zur Rekrutierung des CRBN-Proteins verwendet wird. Lenalidomid-C4-NH2-Hydrochlorid kann mit dem Liganden fÜr Protein durch einen Linker verbunden werden, um PROTAC (Verbindung 24) zu bilden, das IC50-Werte von 0,98 nM und 13,7 nM bei der Hemmung des Wachstums von akuten RS4;11- und MOLM-13-LeukÄmie-Zelllinien aufweist, beziehungsweise.
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Sample solution is provided at 25 µL, 10mM.
Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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