Lenalidomide-C4-NH2 hydrochloride (Synonyms: Cereblon ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride) |
| Catalog No.GC60984 |
El clorhidrato de lenalidomida-C4-NH2 es el ligando Cereblon basado en lenalidomida que se utiliza en el reclutamiento de la proteÍna CRBN. El clorhidrato de lenalidomida-C4-NH2 se puede conectar al ligando de la proteÍna mediante un conector para formar PROTAC (Compuesto 24), que tiene IC50 de 0,98 nM y 13,7 nM en la inhibiciÓn del crecimiento de las lÍneas celulares de leucemia aguda RS4;11 y MOLM-13, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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