Metyrapone (Synonyms: NSC 25265, SU 4885) |
| رقم الكتالوجGC17411 |
Metyrapone (Su-4885) هو مثبط قوي وفعال عن طريق الفم 11β-hydroxylase ومنشط الالتهام الذاتي ، كما أنه يثبط إنتاج الألدوستيرون
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Cas No.: 54-36-4
Sample solution is provided at 25 µL, 10mM.
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Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.Target: CYP11B1Metyrapone is a drug used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing's syndrome (hypercortisolism). Metyrapone blocks cortisol synthesis by reversibly inhibiting steroid 11β-hydroxylase. This stimulates ACTH secretion, which in turn increases plasma 11-Deoxycortisol levels.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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