MST-312 (Synonyms: Telomerase Inhibitor IX) |
| رقم الكتالوجGC18769 |
DB2115 (ثلاثي هيدروكلوريد) هو مثبط قوي لمنظم النخاع الشوكي الرئيسي PU.1يمتلك DB2115 (ثلاثي هيدروكلوريد) القدرة على البحث عن السرطانات ، بما في ذلك السرطانات الدموية مثل اللوكيميا ، بالإضافة إلى الحالات الأخرى المرتبطة بـ PU1 خلل وظيفي (مستخرج من براءة اختراع WO2017223260A1 ، مركب DB2115)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 368449-04-1
Sample solution is provided at 25 µL, 10mM.
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MST312 is a telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay). It is selective for telomerase over DNA polymerase when used at concentrations up to 3 μM. MST312 inhibits growth of U937 cells via telomere shortening (GI50 = 1.7 μM). It reduces cell number and expression of the proliferation marker MIB-1 as well as increases DNA damage in primary pediatric ependymoma tumor cells. MST312 decreases survival of H460 and H1299 non-small cell lung cancer (NSCLC) cells in a dose-dependent manner with a greater effect on the aldehyde dehydrogenase positive (ALDH+) cancer stem cell population. In vivo, MST312 (40 mg/kg) reduces tumor size by 70% in an H460 mouse xenograft model. MST312 also inhibits replication of herpes simplex virus 2 (HSV-2) and a clinical isolate of HSV-1 and decreases accumulation of early and late viral proteins in HEp-2 cells infected with HSV-1.
Review for MST-312
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
Review for MST-312
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