N-Descyclopropanecarbaldehyde Olaparib |
| رقم الكتالوجGC62154 |
N-Descyclopropanecarbaldehyde Olaparib هو نظير لـ Olaparib يحتوي على جزء DOTAN-Descyclopropanecarbaldehyde Olaparib عبارة عن يجند قائم على CRBN لتجميع جديد ثنائي EGFR و PARP PROTAC ، DP-C-4N-Descyclopropanecarbaldehyde Olaparib يمكن أن يكون ذو علامات إشعاعية F-18 أو فلوروفور للتصوير المقطعي بالإصدار البوزيتروني (PET) أو التصوير البصري في عدة أنواع من الورم
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Cas No.: 763111-47-3
Sample solution is provided at 25 µL, 10mM.
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N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib containing DOTA moiety. N-Descyclopropanecarbaldehyde Olaparib is a CRBN-based ligand for synthesizing novel dual EGFR and PARP PROTAC, DP-C-4[1]. N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor[2].
[1]. Tao Huang, et al. Initial evaluation of Cu-64 labeled PARPi-DOTA PET imaging in mice with mesothelioma. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3472-3476.
[2]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.
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