N-Descyclopropanecarbaldehyde Olaparib |
| Katalog-Nr.GC62154 |
N-Descyclopropancarbaldehyd Olaparib ist ein Analogon von Olaparib, das die DOTA-Einheit enthÄlt. N-Descyclopropancarbaldehyd Olaparib ist ein CRBN-basierter Ligand zur Synthese von neuartigem dualem EGFR und PARP PROTAC, DP-C-4. N-Descyclopropancarbaldehyd Olaparib kann als radioaktiv markiertes F-18 oder Fluorophor fÜr die Positronen-Emissions-Tomographie (PET) oder optische Bildgebung bei mehreren Tumorarten verwendet werden.
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Cas No.: 763111-47-3
Sample solution is provided at 25 µL, 10mM.
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N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib containing DOTA moiety. N-Descyclopropanecarbaldehyde Olaparib is a CRBN-based ligand for synthesizing novel dual EGFR and PARP PROTAC, DP-C-4[1]. N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor[2].
[1]. Tao Huang, et al. Initial evaluation of Cu-64 labeled PARPi-DOTA PET imaging in mice with mesothelioma. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3472-3476.
[2]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.
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