Nourseothricin (sulfate) (Synonyms: clonNAT,Streptothricin) |
| رقم الكتالوجGC13632 |
نورسوثريسين (كبريتات) (ستربتوثريسين كبريتات) هو مضاد حيوي واسع الطيف يدمر الغشاء الخارجي للبكتيريا سالبة الجرام وهو علامة انتقائية سائدة لـ Fonsecaea pedrosoi.
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Cas No.: 96736-11-7
Sample solution is provided at 25 µL, 10mM.
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Nourseothricin is a broad-spectrum antibiotic.
Nourseothricin is a broad-spectrum antibiotic derived from Streptomyces noursei.
In vitro: Nourseothricin, represents a mixture of streptothricins, mainly D and F. Although very slowly, nourseothricin was found to be able to pass the outer membrane through the porin pores. It has been also shown that nourseothricin was able to generate some channels into the outer membrane. Moreover, resistant strains containing a streptothricin-inactivating acetyl transferase exhibited an additional protecting system, namely a reduced penetrability of the outer membrane. In addition, such strains indeed could be rendered sensitive via damaging the barrier function of the outer membrane [1].
In vivo: Animal study showed that nourseothricin was preferentially excreted via kidney and signs of nephrotoxicity could be seen. Renal handling of nourseothricin was characterized on renal cortical slices under various experimental conditions. Following administration the renal tubular transport system for organic anions was not influenced by nourseothricin. There was a high degree of accumulation of nourseothricin in renal cortical slices. In contrast to PAH accumulation, there was no influence of nitrogen atmosphere, probenecid or trishydroxyaminomethane on nourseothricin accumulation. Age dependent differences in nourseothricin accumulation did not exist [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Seltmann G. Resistance of Escherichia coli to nourseothricin (streptothricin): sensitization of resistant strains by abolition of its outer membrane resistance. Zentralbl Bakteriol. 1992 Jan;276(2):143-51.
[2] Brunlich H, Hoffmann H, Bocker H. Renal handling of nourseothricin. Pharmazie. 1988 Mar;43(3):200-2.
| Cas No. | 96736-11-7 | SDF | |
| المرادفات | clonNAT,Streptothricin | ||
| Chemical Name | nourseothricin, monosulfate | ||
| Canonical SMILES | O[C@@H]1[C@@H](OC(N)=O)[C@@H](CO)O[C@@H](NC2=N[C@@]3([H])[C@](C(NC[C@H]3O)=O)([H])N2)[C@@H]1NC(C[C@@H](N)CCCN[H])=O.O=S(O)(O)=O | ||
| Formula | C31H58N12O10 • C19H34N8O8 • H2SO4 | M.Wt | 1359.5 |
| الذوبان | ≤10mg/ml in PBS, pH 7.2 | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.7356 mL | 3.6778 mL | 7.3556 mL |
| 5 mM | 0.1471 mL | 0.7356 mL | 1.4711 mL |
| 10 mM | 0.0736 mL | 0.3678 mL | 0.7356 mL |
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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