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Nourseothricin (sulfate) (Synonyms: clonNAT,Streptothricin)

Catalog No.GC13632

Nourseothricin (sulfate) (Streptothricin sulfate)은 그람 음성 박테리아의 외막을 파괴하는 광범위한 항생제이며 Fonsecaea pedrosoi에 대한 지배적 인 선택 마커입니다.

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Nourseothricin (sulfate) Chemical Structure

Cas No.: 96736-11-7

Size 가격 재고 수량
10mM (in 1mL Water)
US$108.00
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5 mg
US$45.00
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10 mg
US$72.00
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50 mg
US$297.00
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100 mg
US$475.00
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500 mg
US$1,425.00
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1g
US$2,280.00
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Nourseothricin is a broad-spectrum antibiotic.

Nourseothricin is a broad-spectrum antibiotic derived from Streptomyces noursei.

In vitro: Nourseothricin, represents a mixture of streptothricins, mainly D and F. Although very slowly, nourseothricin was found to be able to pass the outer membrane through the porin pores. It has been also shown that nourseothricin was able to generate some channels into the outer membrane. Moreover, resistant strains containing a streptothricin-inactivating acetyl transferase exhibited an additional protecting system, namely a reduced penetrability of the outer membrane. In addition, such strains indeed could be rendered sensitive via damaging the barrier function of the outer membrane [1].

In vivo: Animal study showed that nourseothricin was preferentially excreted via kidney and signs of nephrotoxicity could be seen. Renal handling of nourseothricin was characterized on renal cortical slices under various experimental conditions. Following administration the renal tubular transport system for organic anions was not influenced by nourseothricin. There was a high degree of accumulation of nourseothricin in renal cortical slices. In contrast to PAH accumulation, there was no influence of nitrogen atmosphere, probenecid or trishydroxyaminomethane on nourseothricin accumulation. Age dependent differences in nourseothricin accumulation did not exist [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Seltmann G.  Resistance of Escherichia coli to nourseothricin (streptothricin): sensitization of resistant strains by abolition of its outer membrane resistance. Zentralbl Bakteriol. 1992 Jan;276(2):143-51.
[2] Brunlich H, Hoffmann H, Bocker H.  Renal handling of nourseothricin. Pharmazie. 1988 Mar;43(3):200-2.

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