NVS-ZP7-4 |
| رقم الكتالوجGC34323 |
يعد NVS-ZP7-4 مثبطًا لنقل الزنك SLC39A7 (ZIP7) وهو أيضًا أول أداة كيميائية تم الإبلاغ عنها للتحقق من تأثير تعديل مستويات الزنك ER والتحقيق في ZIP7 كعقدة جديدة للأدوية في مسار Notch
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Cas No.: 2349367-89-9
Sample solution is provided at 25 µL, 10mM.
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NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.
NVS-ZP7-4 increases ER zinc levels, suggesting functional modulation of ZIP7[1].
[1]. Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188.
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