NVS-ZP7-4 |
| カタログ番号GC34323 |
NVS-ZP7-4 は亜鉛輸送体 SLC39A7 (ZIP7) 阻害剤であり、ER 亜鉛レベルの調節の影響を調査し、Notch 経路の新しいドラッグ可能なノードとして ZIP7 を調査する最初に報告された化学ツールでもあります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2349367-89-9
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.
NVS-ZP7-4 increases ER zinc levels, suggesting functional modulation of ZIP7[1].
[1]. Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *