Osthenol |
| رقم الكتالوجGC61162 |
Osthenol (Ostenol) ، وهو الكومارين prenylated معزول من الجذور المجففة من Angelica pubescens ، هو مثبط أحادي الأمين أوكسيديز A (hMAO-A) انتقائي وقابل للعكس وتنافسي (Ki = 0.26 ميكرومتر)
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Cas No.: 484-14-0
Sample solution is provided at 25 µL, 10mM.
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Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B[1].
[1]. Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019;29(6):839-843. [2]. Liao ZC, et al. Zhongguo Zhong Yao Za Zhi. 2017;42(15):2999-3003.
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