Osthenol |
| Catalog No.GC61162 |
Angelica pubescens의 말린 뿌리에서 분리된 프레닐화 쿠마린인 Osthenol(Ostenol)은 선택적이고 가역적이며 경쟁적인 인간 모노아민 산화효소-A(hMAO-A) 억제제(Ki=0.26μM)입니다.
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Cas No.: 484-14-0
Sample solution is provided at 25 µL, 10mM.
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Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B[1].
[1]. Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019;29(6):839-843. [2]. Liao ZC, et al. Zhongguo Zhong Yao Za Zhi. 2017;42(15):2999-3003.
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