Osthenol |
| カタログ番号GC61162 |
アンジェリカ・プベセンスの乾燥根から分離されたプレニル化クマリンであるオステノール (Ostenol) は、選択的、可逆的、かつ競合的なヒトモノアミン酸化酵素-A (hMAO-A) 阻害剤 (Ki = 0.26 μM) です。
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Cas No.: 484-14-0
Sample solution is provided at 25 µL, 10mM.
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Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B[1].
[1]. Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019;29(6):839-843. [2]. Liao ZC, et al. Zhongguo Zhong Yao Za Zhi. 2017;42(15):2999-3003.
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